https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1
Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
Abstract
We
 are currently witnessing a major epidemic caused by the 2019 novel 
coronavirus (2019- nCoV). The evolution of 2019-nCoV remains elusive.  
We found 4 insertions in the spike glycoprotein (S) which are unique to 
the 2019-nCoV and are not present in other coronaviruses.  Importantly, 
amino acid residues in all the 4 inserts have identity or similarity to 
those in the HIV-1 gp120 or HIV-1 Gag.   Interestingly, despite the 
inserts being discontinuous on the primary amino acid sequence, 
3D-modelling of the 2019-nCoV suggests that they converge to constitute 
the receptor binding site.  The finding of 4 unique inserts in the 
2019-nCoV, all of which have identity /similarity to amino acid residues
 in key structural proteins of HIV-1 is unlikely to be fortuitous in 
nature. This work provides yet unknown insights on 2019-nCoV and sheds 
light on the evolution and pathogenicity of this virus with important 
implications for diagnosis of this virus. 6park.com
我们目前正在目睹由2019年新型冠状病毒（2019-nCoV）引起的主要流行病。 2019-nCoV的发展仍然难以捉摸。 我们在刺突糖蛋白（S）中发现了4个插入，这是2019-nCoV所独有的，在其他冠状病毒中不存在。 重要的是，所有4个插入片段中的氨基酸残基均与HIV-1 gp120或HIV-1 Gag中的氨基酸残基具有相同性或相似性。 有趣的是，尽管插入片段在一级氨基酸序列上是不连续的，但2019-nCoV的3D建模表明它们会聚在一起构成受体结合位点。 在2019-nCoV中发现4个独特的插入片段，这些插入片段都与HIV-1关键结构蛋白中的氨基酸残基具有同一性/相似性，这在自然界不太可能是偶然的。 这项工作提供了关于2019-nCoV的未知见解，并阐明了该病毒的进化和致病性，对诊断该病毒具有重要意义。


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