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新冠痊愈患者体内发现病毒序列已经植入人体基因组。跟艾滋一样，永远无非消除。中国人恐怕永远要戴口罩了 6park.comReverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues
6park.comLiguo Zhang, Alexsia Richards, View ORCID ProfileM. Inmaculada Barrasa, View ORCID ProfileStephen H. Hughes, View ORCID ProfileRichard A. Young, and Rudolf Jaenisch 6park.comaWhitehead Institute for Biomedical Research, Cambridge, MA 02142;bHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702;cDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142 6park.comHide authors and affiliations
PNAS May 25, 2021 118 (21) e2105968118; https://doi.org/10.1073/pnas.2105968118 6park.comContributed by Rudolf Jaenisch, April 19, 2021 (sent for review March 29, 2021; reviewed by Anton Berns and Anna Marie Skalka)
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Relationship between Research Article and Letter - August 03, 2021 6park.comArticle Figures & SI Info & Metrics PDF 6park.comSignificance
An unresolved issue of SARS-CoV-2 disease is that patients often remain positive for viral RNA as detected by PCR many weeks after the initial infection in the absence of evidence for viral replication. We show here that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of the infected cell and be expressed as chimeric transcripts fusing viral with cellular sequences. Importantly, such chimeric transcripts are detected in patient-derived tissues. Our data suggest that, in some patient tissues, the majority of all viral transcripts are derived from integrated sequences. Our data provide an insight into the consequence of SARS-CoV-2 infections that may help to explain why patients can continue to produce viral RNA after recovery.
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