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辉瑞疫苗在现实中发现94%有效
送交者: nowhere1[♂☆★★✦娱乐人生✦★★☆♂] 于 2021-02-25 15:25 已读 1001 次  

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辉瑞疫苗在现实世界中发现94%有效
作者:Maayan Lubell,阿里·拉比诺维奇(Ari Rabinovitch)
耶路撒冷(路透社)-辉瑞/ BioNTech疫苗的第一个大型现实世界研究得到独立审查,显示该疫苗在预防COVID-19方面非常有效,对于那些迫切希望结束封锁和重新开放经济的国家而言,这可能是一个具有里程碑意义的时刻。
到目前为止,有关COVID-19疫苗功效的大多数数据都是在临床试验中处于受控条件下的,因此,如何将结果转化为具有不可预测变量的现实世界尚不确定。 
以色列的一项研究-进入世界上最快的实验室之一,提供了丰富的数据来源-开展了两个月的研究,结果显示,在所有年龄段中,两剂的Pfizer镜头可将有症状的COVID-19病例减少94%,而严重疾病的发病率则几乎降低了。
根据周三在《新英格兰医学杂志》上发表并经过同行评审的数据,对约120万人的研究还显示,两周后,单次注射对预防症状性感染的有效率为57%。 
Clalit研究所的研究结果与去年的临床试验结果相近,后者发现两剂有效率为95%。
Pfizer vaccine found 94% effective in real world
By Maayan Lubell, Ari Rabinovitch 6park.com

JERUSALEM (Reuters) - The first big real-world study of the Pfizer/BioNTech vaccine to be independently reviewed shows the shot is highly effective at preventing COVID-19, in a potentially landmark moment for countries desperate to end lockdowns and reopen economies. 6park.com

Up until now, most data on the efficacy of COVID-19 vaccines has come under controlled conditions in clinical trials, leaving an element of uncertainty over how results would translate into the real world with its unpredictable variables. 6park.com

The research in Israel - two months into one of the world’s fastest rollouts, providing a rich source of data - showed two doses of the Pfizer shot cut symptomatic COVID-19 cases by 94% across all age groups, and severe illnesses by nearly as much. 6park.com

The study of about 1.2 million people also showed a single shot was 57% effective in protecting against symptomatic infections after two weeks, according to the data published and peer-reviewed in the New England Journal of Medicine on Wednesday. 6park.com

The results of the study for the Clalit Research Institute were close to those in clinical trials last year which found two doses were found to be 95% effective. 6park.com

ADVERTISEMENT 6park.com

“We were surprised because we expected that in the real-world setting, where cold chain is not maintained perfectly and the population is older and sicker, that you will not get as good results as you got in the controlled clinical trials,” senior study author Ran Balicer told Reuters. “But we did and the vaccine worked as well in the real world.” 6park.com

“We have shown the vaccine to be as effective in very different sub-groups, in the young and in the old in those with no co-morbidities and in those with few co-morbidities,” he added. 6park.com

The study also suggests the vaccine, developed by U.S drugmaker Pfizer and Germany’s BioNTech, is effective against the coronavirus variant first identified in the UK. Researchers said they could not provide a specific level of efficacy, but the variant was the dominant version of the virus in Israel at the time of the study. 6park.com

The research did not shed light on how the Pfizer shot will fare against another variant, now dominant in South Africa, that has been shown to reduce the efficacy of other vaccines. 6park.com

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贴主:nowhere1于2021_02_25 15:31:12编辑

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